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KMID : 0861120080120030047
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Korean Journal of Oriental Preventive Medicine
2008 Volume.12 No. 3 p.47 ~ p.58
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Anticancer and Antioxidant Effects of Saturated Fatty Acid against Skin Cancer Cell Lines
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Han Du-Seok
Park Yeun-Kju
Kim Hyun-Jin
Lee Jae-Sug
Baek Seung-Hwa
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Abstract
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The anticancer and antioxidant effect of different lengths of saturated fatty acids was tested on NIH3T3 fibroblasts and human skin melanoma cellsn in this study. The cell existence rate and antioxidizing capacity and optic reservation of cells were observed. This saturated fatty acid was concentration-dependent. IC50 Concentrations in NIH3T3 fibroblasts, human skin melanoma cells and DPPH radical scavenging activity of fatty acid was increasing the order of carbochain length ; caprylic acid < lauric acid < palmitic acid < stearic acid. The reduction in cell number and morphological change in human skin melanoma cells was increasing the order of carbochain length ; caprylic acid < lauric acid < palmitic acid < stearic acid. These results suggest that carbochain length of fatty acid can be used as structure-activity relationships for anticancer and antioxidant.
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KEYWORD
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Carbochain length, anticancer, antioxidant, saturated fatty acids, NIH3T3 fibroblasts, human skin melanoma cells
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